Studies promoting use of antidepressants for postoperative pain may be premature, review finds

Chicago — (August 19, 2014) 

Antidepressants are known to provide effective pain relief for various chronic pain conditions; however, the jury is still out on their use in treating the millions of patients who suffer from acute or chronic pain following surgery.  A first-of-its-kind literature review published in the September issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists® (ASA®), suggests although a majority of studies report positive outcomes, there is currently insufficient evidence to support the clinical use of antidepressants for the treatment of postoperative pain.

“There is a need for improved treatment options in the management of postoperative pain, and antidepressants could potentially be a valuable addition,” said Ian Gilron, M.D., lead author, professor and director of clinical pain research at Queen’s University in Ontario, Canada.  “Our review of the literature showed several positive trial results, but we also found important research limitations in the studies, indicating a need for higher quality, more definitive trials on antidepressant use for postsurgical pain.”

In the study, researchers performed a systematic review of all currently published clinical trials on antidepressants and postoperative pain.  Fifteen studies on acute (985 patients) and three studies on chronic (565 patients) postoperative pain were included.  Extracted data from the studies included pain at rest and with movement, pain relief, adverse effects and other outcomes (e.g. mood, sleep, physical function).  

Nearly half of the studies (eight of the acute and one of the chronic pain) suggested that antidepressants resulted in significant treatment benefits over placebo.  However, researchers identified several important limitations in many of the trials (e.g. too few patients, inadequate safety evaluation and procedure specificity, variable dosing, limited pain assessment, etc.) that indicated a need for additional studies.

According to the review, future clinical trials should optimize dosing, timing and duration of antidepressant treatment, trial size, patient selection, safety evaluation and reporting, procedure specificity, and assessment of movement-evoked pain relevant to postoperative functional recovery. Trials should also better define the risk-benefit ratio of antidepressants in postoperative pain management since these drugs can be associated with serious adverse effects in the time around surgery, the authors note.

More than 40 million surgical procedures are performed in North America alone each year and the majority of these are associated with moderate to severe acute pain in the days to weeks immediately following surgery.  Additionally, a substantial proportion of surgical patients experience chronic postoperative pain many months or even years after their original surgery.  

THE AMERICAN SOCIETY OF ANESTHESIOLOGISTS

Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 52,000 members organized to raise and maintain the standards of the medical practice of anesthesiology. ASA is committed to ensuring physician anesthesiologists evaluate and supervise the medical care of patients before, during and after surgery to provide the highest quality and safest care every patient deserves.

For more information on the field of anesthesiology, visit the American Society of Anesthesiologists online at asahq.org. To learn more about the role physician anesthesiologists play in ensuring patient safety, visit asahq.org/WhenSecondsCount. Join the ANESTHESIOLOGYTM 2014 social conversation today. Like ASA on Facebook, follow ASALifeline on Twitter and use the hashtag #ANES2014.

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Contact:

American Society of Anesthesiologists
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