Notice: Get a jump on 2015 — Pay your 2015 ASA membership dues now!

>

MEETINGS / EVENTS

RSS

January 23 - 25 2015, 12:00 AM - 12:00 AM

ASA PRACTICE MANAGEMENT 2015

February 07 - 08 2015, 12:00 AM - 12:00 AM

ASA Certificate in Business Administration 2015

June 26 - 28 2015, 12:00 AM - 12:00 AM

Annual Perioperative Surgical Home Summit

>

FDA MEDWATCH ALERTS

December 18, 2014

0.9 Percent Sodium Chloride Injection USP in 100 mL MINI-BAG PLUS Container by Baxter: Recall - Particulate Matter

Summary:

FDA MedWatch Recall - Particulate Matter

November 21, 2014

FDA MedWatch - Respironics California, Esprit V1000 and V200 Ventilators: Class I Recall - Power Failure May Occur

Summary:

FDA MedWatch Respironics California Esprit V1000 and V200 Ventilators Class I Recall

November 21, 2014

FDA MedWatch - Highly Concentrated Potassium Chloride Injection, 10 mEq per 100 mL by Baxter: Recall - Mislabeled

Summary:

Highly Concentrated Potassium Chloride Injection 10 mEq per 100 mL by Baxter Recall Mislabeled

>

ASA FEATURED PRODUCT

Add this product to your shopping cart

Self-Education and Evaluation (SEE) Program

SKU: 30701-14CE

... Read more »

Single Copies, Member Price: $360

Study Indicates Opiates Already in Body May Encourage Cancer Growth, Certain Medications Could Slow It

Chicago — (December 12, 2012) 

A study led by University of Chicago researcher Patrick A. Singleton, Ph.D. and published in the journal Anesthesiology has shown that, even without the addition of further opioids such as morphine, opioids already in the body can enhance the malignant tendencies of human cancer cells.

Dr. Singleton’s study, which won the award for Best Basic Science Abstract at the ANESTHESIOLOGY™ 2012 annual meeting, adds support to mounting evidence that the mu opioid receptor in cancer cells influences cancer progression and spread, and could become a therapeutic target for cancer treatment.

“If confirmed clinically, this could influence how we do surgical anesthesia for our cancer patients,” said Dr. Singleton, who is Assistant Professor of Medicine at the University of Chicago Medical Center. “There is epidemiological evidence to suggest that the type of anesthesia used during cancer surgery may influence tumor recurrence.”

In their study, Dr. Singleton and his research team, including Jonathan Moss, M.D., Ph.D., injected human lung cancer cells with additional copies of the mu opioid receptor into mice based on their prior observations that cells from certain types of human lung cancer had five to 10 times as many opioid receptors as normal cells. Tumors in the mice injected with the cancer cells having the additional copies of the mu opioid receptor grew more than twice as fast as those injected with cells that lacked the extra receptors, and were 20 times more likely to spread to other parts of the body.

Dr. Moss, who has researched the effects of opioids on cancer extensively, suggests that these results support the growing focus of a potential therapeutic role for drugs known as opioid antagonists, one of which is called methylnaltrexone (MNTX). MNTX is approved to treat opioid-induced constipation without disrupting pain relief in palliative care patients. According to Dr. Moss, Professor of Anesthesiology and Critical Care at the University of Chicago Medical Center, the beneficial effects could be far greater:

“In compassionate-use studies prior to its approval, we noted that some cancer patients receiving MNTX to treat opioid-induced constipation lived longer than expected,” said Dr. Moss. “These were patients with advanced cancer and a life expectancy of one of two months, yet several lived another five or six months. This led us to question whether these patients were living longer because of better gut function or whether there was something about blocking the mu opioid receptor that influenced tumor progression.”

In a series of laboratory studies, Drs. Singleton and Moss found that drugs which blocked mu opioid receptors reduced cancer growth in animals and helped prevent further invasion and spread of cancer cells. Further, tumors did not grow in mice that lacked the mu opioid receptor.

Despite the growing body of laboratory evidence suggesting that the mu opioid receptor plays a role in tumor progression, Drs. Singleton and Moss cautioned that no clinical trials exist that demonstrate a direct effect of the receptor blockade on cancer growth or treatment.

For more information, visit the Anesthesiology website at anesthesiology.org.

Dr. Moss, one of the developers of methylnaltrexone, receives royalties from its sale and is a paid consultant for its distributor, Salix Pharmaceuticals Inc.

THE AMERICAN SOCIETY OF ANESTHESIOLOGISTS

Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 52,000 members organized to raise and maintain the standards of the medical practice of anesthesiology. ASA is committed to ensuring physician anesthesiologists evaluate and supervise the medical care of patients before, during and after surgery to provide the highest quality and safest care every patient deserves.

For more information on the field of anesthesiology, visit the American Society of Anesthesiologists online at asahq.org . To learn more about the role physician anesthesiologists play in ensuring patient safety, visit asahq.org/WhenSecondsCount. Like ASA on Facebook , follow ASALifeline on Twitter and follow ASA on LinkedIn .

###

Contact:

American Society of Anesthesiologists
pr@asahq.org
847-825-5586